The liver contains distinct interconnected networks of CX3CR1⁺ macrophages, XCR1⁺ type 1 and CD301a⁺ type 2 conventional dendritic cells embedded within portal tracts.

ABSTRACT: Portal tracts are key intrahepatic structures where leukocytes accumulate during immune responses. They contain the blood inflow, which includes portal blood from the gut, and lymphatic and biliary outflow of the liver, and as such represent a key interface for potential pathogen entry to the liver. Myeloid cells residing in the interstitium of the portal tract might play an important role in the surveillance or prevention of pathogen dissemination; however, the exact composition and localization of this population has not been explored fully. Our in-depth characterization of portal tract myeloid cells revealed that in addition to T lymphocytes, portal tracts contain a heterogeneous population of MHCII^high myeloid cells with potential antigen presenting cell (APC) function. Thes

SUBMITTER: English K 

PROVIDER: S-EPMC9541163 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature