Identifying organic chemicals not subject to bioaccumulation in air-breathing organisms using predicted partitioning and biotransformation properties.

ABSTRACT: Because the respiration processes contributing to the elimination of organic chemicals deviate between air- and water-breathing organisms, existing and widely used procedures for identifying chemicals not subject to bioaccumulation in aquatic organisms based on the octanol-water partition ratio K_OW need to be complemented with similar procedures for organisms respiring air. Here, we propose such a procedure that relies on the comparison of a compound's predicted K_OW , octanol-air partition ratio K_OA , and biotransformation half-life HL_B with three threshold values, below which elimination is judged to be sufficiently rapid to prevent bioaccumulation. The method allows for the consideration of the effect of dissociation on the efficiency of urinar

SUBMITTER: Wania F 

PROVIDER: S-EPMC9541168 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature