Oral digoxin effects on exercise performance, K⁺ regulation and skeletal muscle Na⁺ ,K⁺ -ATPase in healthy humans.

ABSTRACT: We investigated whether digoxin lowered muscle Na⁺ ,K⁺ -ATPase (NKA), impaired muscle performance and exacerbated exercise K⁺ disturbances. Ten healthy adults ingested digoxin (0.25 mg; DIG) or placebo (CON) for 14 days and performed quadriceps strength and fatiguability, finger flexion (FF, 105%_{peak-workrate} , 3 × 1 min, fourth bout to fatigue) and leg cycling (LC, 10 min at 33% VO2peak${\rm{V}}_{{{\rm{O}}}_{\rm{2}}{\rm{peak}}}$ and 67% VO2peak${\rm{V}}_{{{\rm{O}}}_{\rm{2}}{\rm{peak}}}$ , 90% VO2peak${\rm{V}}_{{{\rm{O}}}_{\rm{2}}{\rm{peak}}}$ to fatigue) trials using a double-blind, crossover, randomised, counter-balanced design. Arterial (a) and antecubital venous (v) blood was sampled (FF, LC) and muscle biopsied (LC, rest, 67% VO2peak${\rm{V}

SUBMITTER: Sostaric S 

PROVIDER: S-EPMC9541254 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature