D-dimer testing for early detection of venom-induced consumption coagulopathy after snakebite in Australia (ASP-29).

ABSTRACT:

Objective

To assess the accuracy and marginal value of quantitative D-dimer testing for diagnosing venom-induced consumption coagulopathy (VICC) in people bitten by Australian snakes.

Design, setting

Analysis of data for suspected and confirmed cases of snakebite collected prospectively by the Australian Snakebite Project, 2005-2019, from 200 hospitals across Australia.

Participants

1363 patients for whom D-dimer was quantitatively assessed within 24 hours of suspected or confirmed snakebite.

Main outcome measures

Diagnostic performance of quantitative D-dimer testing for detecting systemic envenoming with VICC (area under the receiver operating characteristic curve, AUC); optimal D-dimer cut-off value (maximum sum of sensitivity and specificity).

Results

SUBMITTER: Isbister GK 

PROVIDER: S-EPMC9541317 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature