BeeGUTS-A Toxicokinetic-Toxicodynamic Model for the Interpretation and Integration of Acute and Chronic Honey Bee Tests.

ABSTRACT: Understanding the survival of honey bees after pesticide exposure is key for environmental risk assessment. Currently, effects on adult honey bees are assessed by Organisation for Economic Co-operation and Development standardized guidelines, such as the acute and chronic oral exposure and acute contact exposure tests. The three different tests are interpreted individually, without consideration that the same compound is investigated in the same species, which should allow for an integrative assessment. In the present study we developed, calibrated, and validated a toxicokinetic-toxicodynamic model with 17 existing data sets on acute and chronic effects for honey bees. The model is based on the generalized unified threshold model for survival (GUTS), which is able to integrate the differen

SUBMITTER: Baas J 

PROVIDER: S-EPMC9541331 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature