Clinical utility of family history of depression for prognosis of adolescent depression severity and duration assessed with predictive modeling.

ABSTRACT:

Background

Family history of depression (FHD) is a known risk factor for the new onset of depression. However, it is unclear if FHD is clinically useful for prognosis in adolescents with current, ongoing, or past depression. This preregistered study uses a longitudinal, multi-informant design to examine whether a child's FHD adds information about future depressive episodes and depression severity applying state-of-the-art predictive out-of-sample methodology.

Methods

We examined data in adolescents with current or past depression (age 11-17 years) from the National Institute of Mental Health Characterization and Treatment of Adolescent Depression (CAT-D) study. We asked whether a history of depression in a first-degree relative was predictive of depressive episode duration

SUBMITTER: Gorham LS 

PROVIDER: S-EPMC9541414 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature