Glucocorticoid receptor and androgen receptor-targeting therapy in patients with castration-resistant prostate cancer.

ABSTRACT:

Objective

The glucocorticoid receptor (GR) promotes resistance to androgen receptor (AR)-targeting therapies in castration-resistant prostate cancer (CRPC) by bypassing AR blockade. However, the clinical relevance of evaluating GR expression in patients with CRPC has not been determined. The present study investigated the association of relative GR expression in CRPC tissue samples with treatment response to AR-targeting therapy.

Methods

Levels of GR, AR-FL, and AR-V7 mRNAs were measured in prostate cancer tissue from prospectively enrolled CRPC patients who were starting treatment. Patients were divided into groups with high and low AR-V7/AR-FL ratios and with high and low GR/AR-FL ratios. The primary endpoint was prostate-specific antigen (PSA) respons

SUBMITTER: Pak S 

PROVIDER: S-EPMC9541428 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature