Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

ABSTRACT:

Background

Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP). Spatial precision of LC imaging is improved with ultrahigh field 7 T magnetic resonance imaging.

Objectives

This study aimed to characterize the spatial patterns of LC pathological change in PD and PSP and the transdiagnostic relationship between LC signals and neuropsychiatric symptoms.

Methods

Twenty-five people with idiopathic PD, 14 people with probable PSP-Richardson's syndrome, and 24 age-matched healthy controls were recruited. Participants underwent clinical assessments and high-resolution (0.08 mm³ ) 7 T-magnetization-transfer imaging to measure LC integrity in vivo. Spatial pat

SUBMITTER: Ye R 

PROVIDER: S-EPMC9541468 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature