Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin.

ABSTRACT: Many brain insults and injuries are "epileptogenic": they increase the risk of developing epilepsy. It is desirable to identify treatments that are "antiepileptogenic": treatments that prevent the development of epilepsy, if administered after the occurrence of an epileptogenic insult. Current antiepileptic drugs are not antiepileptogenic, but evidence of antiepileptogenic efficacy is accumulating for a growing number of other compounds. From among these candidate compounds, statins are deserving of particular attention because statins are reported to be antiepileptogenic in more published studies and in a wider range of brain insults than any other individual or class of compounds. Although many studies report the antiepileptogenic effect of statins, it is unclear how many studies provide

SUBMITTER: Hufthy Y 

PROVIDER: S-EPMC9541605 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature