(NZW × BXSB) F1 male mice: An unusual, severe and fatal mouse model of lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune/inflammatory disease. The heterogeneity and complexity of clinical presentation has made it challenging to study or treat this syndrome. The (NZW×BXSB) F1 lupus-prone male mouse model of this disease is potentially useful to study mechanism and treatment modalities, but there is a lack of information about this model's characterization and disease progression. Therefore, the aim was to examine this lupus model's physical/clinical disease presentation and its immunological status.

Materials and methods

Clinical and physical status were observed in 8- and 16-week-old male and female (± 1 week) (NZW/LacJ x BXSB/MpJ) F1 mice (n = 8 per group). Young males (8 ± 1 week) without disease and female (16 ± 1 week) m

SUBMITTER: Almizraq RJ 

PROVIDER: S-EPMC9541624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature