Reversal of obesity development in Ceacam1^-/- male mice by bone marrow transplantation or introduction of the human CEACAM1 gene.

ABSTRACT:

Objective

Although Ceacam1^-/- male mice become obese on normal chow, the effect of bone marrow transplantation or introduction of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) gene has not been studied, to the knowledge of the authors.

Methods

This study analyzed Ceacam1^-/- mice on normal diet or high-fat diet (HFD), including effects of bone marrow transplantation or introduction of the CEACAM1 gene.

Results

Male Ceacam1^-/- mice on normal diet versus HFD for 24 weeks gained significantly more weight than controls, and Ceacam1^-/- mice aged up to 2 years had a high frequency of liver cancer. Transplantation of wild-type bone marrow into Ceacam1^-/- mice or introduction of the human CEACAM1

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9541698 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature