The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.

ABSTRACT: Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MOOD and psychiatric disorders beyond genetic correlation to better characterize putative shared genetic determinants. GWAS summary statistics for schizophrenia (SCZ, n = 105,318), bipolar disorder (BIP, n = 413,466), DEP (n = 450,619), attention-deficit hyperactivity disorder (ADHD, n = 53,293), and MOOD (n = 363,705) were analyzed using the bivariate causal mixture model and conjunctional false discovery rate methods. MOOD correlated positively with all psychiatric disorders, but with wide variation in strength (r_g  = 0.10-0.62). Of

SUBMITTER: Hindley G 

PROVIDER: S-EPMC9541703 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature