Diagnostic Accuracy of Therapeutic Drug Monitoring During Tuberculosis Treatment.

ABSTRACT: Patients with tuberculosis (TB) coinfected with HIV are more likely to have low blood concentrations of the first-line anti-TB drugs (associated with poor outcomes). Therapeutic drug monitoring (TDM) is recommended for certain patient populations with TB at increased risk for a poor outcome. Our objective was to estimate the diagnostic accuracy of a 2-hour TDM serum sample for the first-line anti-TB drugs among patients with HIV/TB and evaluate the information gained by an additional 6-hour sample. We created a virtual (n = 1000) HIV/TB patient population and performed pharmacokinetic simulations using published population models for isoniazid, rifampin, pyrazinamide, and ethambutol. We performed receiver operating characteristic analysis to compare the diagnostic performance of a single 2

SUBMITTER: Anderson G 

PROVIDER: S-EPMC9541759 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature