Dataset Information

Carcinogenic effects of prolonged daily low-emission phototherapy in psoriasis.

ABSTRACT:

Background

Low-dose UV treatment has been shown to be effective in mild psoriasis. However, the prolonged use of this treatment modality may raise concerns about its safety. These concerns are mainly focused on potential carcinogenic risks and overuse of this treatment modality.

Objectives

This study was set out to evaluate possible carcinogenic risks of prolonged low-dose phototherapy.

Methods

Three groups of psoriasis patients were evaluated: patients with local treatment only (n = 15); low-dose UV treatment at home for at least 18 months (n = 39); and patients with conventional NB-UVB (n = 8). Patients underwent visual inspection for signs of photoageing, and p53, CPDs and γH2AX were measured in skin biopsies. Patients undergoing low-dose phototherapy answered a survey about their recent patterns of use in a survey.

Results

In the skin biopsies, low-dose UV treatment caused a lower amount of CPDs (p = .016) and p53 (p = .015) than NB-UVB. γH2AX did not show a significant difference. Self-report in patients undergoing low-dose phototherapy showed only one case of overuse (2.7%). Visual skin inspection showed no difference in signs of photoageing in the three groups.

Conclusion

Prolonged treatment with low-dose UV for 18 months appears at least as safe as a course of conventional NB-UVB.

SUBMITTER: Franken SM

PROVIDER: S-EPMC9541771 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Carcinogenic effects of prolonged daily low-emission phototherapy in psoriasis.

Franken Sylvie Mireille SM Spiekstra Sander Wiebrand SW Waaijman Taco T Lissenberg-Witte Birgit B Rustemeyer Thomas T

Photodermatology, photoimmunology & photomedicine 20220117 5

<h4>Background</h4>Low-dose UV treatment has been shown to be effective in mild psoriasis. However, the prolonged use of this treatment modality may raise concerns about its safety. These concerns are mainly focused on potential carcinogenic risks and overuse of this treatment modality.<h4>Objectives</h4>This study was set out to evaluate possible carcinogenic risks of prolonged low-dose phototherapy.<h4>Methods</h4>Three groups of psoriasis patients were evaluated: patients with local treatment ...[more]

PMID: 34967469

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Project description:Psoriasis is a common chronic inflammatory and hyperproliferative immune-mediated skin disorder. Narrow-band UVB (NB-UVB) phototherapy is a convenient first-line treatment of psoriasis, though the mechanisms underlying its efficacy have not been completely elucidated. In order to improve our understanding of NB-UVB phototherapy, gene expression profiling was used to characterize gene expression in lesional epidermis from psoriasis patients undergoing NB-UVB phototherapy. Increased expression of melanogenesis pathway genes was observed to be the earliest response. At the end of treatment, genes involved in diverse biological processes were affected, such as pigmentation, cell adhesion, ectodermal development and metabolism. The relationship between gene expression and treatment outcome was further studied using Partial Least Squares Discriminant Analysis (PLS-DA). Gene ontology analysis showed that genes responding to phototherapy and highly correlated to treatment outcome were involved in oxidation reduction, growth and mitochondria organization. In particular SPATA18, a key regulator of mitochondria quality, was found to be significantly downregulated in psoriasis, and its upregulation following phototherapy was required for optimal clinical improvement. Our data suggest that oxidation reduction is a critical event for the resolution of psoriatic plaques. Twelve patients diagnosed with plaque type psoriasis were recruited to the study. NB-UVB irradiation was administered to the whole body two to three times a week. Treatment comprising approximately 24 sessions was given during two to three months. A total of six 4 mm diameter punch biopsies were taken from lesions on each psoriasis patient: two prior to UV treatment (pre-UV), two at the middle stage of UV treatment (after about one month of treatment, mid-UV) and two before the last treatment session (post-UV). Twelve healthy age-, sex- and skin type-matched volunteers were also recruited and two punch biopsies were taken from the buttocks. RNA was extracted from Laser capture microdissected epidermis.

Dataset Information

Carcinogenic effects of prolonged daily low-emission phototherapy in psoriasis.

Background

Objectives

Methods

Results

Conclusion

Publications

Carcinogenic effects of prolonged daily low-emission phototherapy in psoriasis.

Similar Datasets

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