Ontology highlight
ABSTRACT:
SUBMITTER: Drai RV
PROVIDER: S-EPMC9541865 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Drai Roman V RV Karonova Tatiana L TL Mayorov Alexander Y AY Makarenko Igor E IE Dorotenko Artem R AR Kulesh Viktoria S VS Kovalik Vladislav V VV Andreeva Alena T AT
Clinical pharmacology in drug development 20220301 8
Insulin aspart is a short-acting insulin analogue that is used to control postprandial glycemia levels in diabetic patients. The aim of this clinical trial was to compare the pharmacokinetics and pharmacodynamics of GP40071 (GP-Asp) and NovoRapid Penfill (Novo-Asp) in a hyperinsulinemic euglycemic clamp (HEC). This trial was conducted as a part of a GP40071 biosimilar clinical development program. This was a phase I randomized, double-blind, two-period crossover study. Twenty-six healthy male vo ...[more]