The effect of helminth infection on vaccine responses in humans and animal models: A systematic review and meta-analysis.

ABSTRACT: Vaccination has potential to eliminate infectious diseases. However, parasitic infections such as helminths may hinder vaccines from providing optimal protection. We reviewed existing literature on the effects of helminth infections and their treatment on vaccine responses in humans and animals. We searched literature until 31 January 2022 in Medline, EMBASE, Global health, Scopus, and Web of science; search terms included WHO licensed vaccines and human helminth types. Standardized mean differences (SMD) in vaccine responses between helminth infected and uninfected or anthelminthic treated and untreated individuals were obtained from each study with suitable data for meta-analysis, and combined using a random effects model. Analysis was stratified by whether helminth exposure was direct o

SUBMITTER: Natukunda A 

PROVIDER: S-EPMC9542036 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature