Is cyclooxygenase-1 involved in neuroinflammation?

ABSTRACT:

Purpose

Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX). The inducible COX-2 subtype has been associated with inflammation, whereas the constitutively expressed COX-1 subtype is generally considered as a housekeeping enzyme. However, recent evidence suggests that COX-1 can also be upregulated and may play a prominent role in the brain during neuroinflammation. In this review, we summarize the evidence that supports this involvement of COX-1.

Methods

Five databases were used to retrieve relevant studies that addressed COX-1 in the context of neuroinflammation. The search resulted in 32 article

SUBMITTER: Ghazanfari N 

PROVIDER: S-EPMC9542093 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature