Natural history and burden of Huntington's disease in the UK: A population-based cohort study.

ABSTRACT:

Background

Huntington's disease (HD) is a rare neurodegenerative disease that presents with progressive psychological, cognitive and motor impairment. These diverse symptoms place a high burden on the patient, families and the healthcare systems they rely on. This study aimed to describe the epidemiology and clinical burden in individuals with HD compared with controls from the general population.

Methods

This cohort study utilised data from general practitioner medical records to estimate the prevalence and incidence of HD between January 2000 and December 2018. A cohort of incident HD cases were matched 1:3 to controls from the general population, in whom common clinical diagnoses, medications and healthcare interventions were compared at the time of first recorded diagnos

SUBMITTER: Furby H 

PROVIDER: S-EPMC9542098 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature