Paternal use of medications for inflammatory bowel disease and the risk of hospital-diagnosed infections in the offspring: a nationwide cohort study.

ABSTRACT:

Background

Information regarding the impact of paternal inflammatory bowel disease (IBD) medications on child outcomes is scarce.

Aim

To examine the risk of childhood infections associated with fathers' use of anti-inflammatory/immunosuppressive medications taken before conception.

Methods

This is a nationwide cohort study based on Danish health registries, comprising all live-born singleton children born between January 1997 and February 2019 who were fathered by men with IBD. Exposed cohorts included children fathered by men treated with 5-aminosalicylates (5-ASAs), thiopurines, corticosteroids or anti-tumour necrosis factor-α (anti-TNF-α) agents within 3 months before conception. The unexposed cohort included children not exposed to paternal IBD medications. Outcom

SUBMITTER: Friedman S 

PROVIDER: S-EPMC9542174 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature