Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn's disease patients.
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ABSTRACT: Abbreviations
AIEC Adherent-Invasive Escherichia coli; BSA Bovine serum albumin; CD Crohn's disease; CEABAC10 Carcinoembryonic antigen bacterial artificial chromosome 10; CEACAM Carcinoembryonic antigen-related cell adhesion molecule; FBS Fetal bovine serum; IBD Inflammatory Bowel Disease; HAT Histone acetyltransferase; HDAC Histone deacetylase; kDa KiloDalton; SAHA Suberoylanilide Hydroxamic Acid; Scr Scramble.
SUBMITTER: Chervy M
PROVIDER: S-EPMC9542275 | biostudies-literature | 2022 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn's disease patients.
Chervy Mélissa M Sivignon Adeline A Dambrine Flavie F Buisson Anthony A Sauvanet Pierre P Godfraind Catherine C Allez Matthieu M Le Bourhis Lionel L The Remind Group Barnich Nicolas N Denizot Jérémy J
Gut microbes 20220101 1
<h4>Abstract</h4>Adherent-invasive Escherichia coli (AIEC), which abnormally colonize the ileal mucosa of Crohn’s disease (CD) patients, are known to contribute to the etiopathogenesis of CD. Molecular mechanisms favoring AIEC ileal colonization have not been completely characterized yet. The aim of this study was to investigate whether epigenetic regulators histone deacetylases (HDAC) expression in intestinal epithelial cells of CD patients regulate Enterobacteria and AIEC encroachment to intes ...[more]
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