Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.

ABSTRACT: A complex interplay of genetic and environmental risk factors influence global brain structural alterations associated with brain health and disease. Epigenome-wide association studies (EWAS) of global brain imaging phenotypes have the potential to reveal the mechanisms of brain health and disease and can lead to better predictive analytics through the development of risk scores.We perform an EWAS of global brain volumes in Generation Scotland using peripherally measured whole blood DNA methylation (DNAm) from two assessments, (i) at baseline recruitment, ~6 years prior to MRI assessment (N = 672) and (ii) concurrent with MRI assessment (N=565). Four CpGs at baseline were associated with global cerebral white matter, total grey matter, and whole-brain volume (Bonferroni p≤7.41×10^-8

SUBMITTER: Barbu MC 

PROVIDER: S-EPMC9542280 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature