Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease.

ABSTRACT:

Background

Cognitive impairment is common in neurological presentations of Wilson's disease (WD). Various domains can be affected, and subclinical deficits have been reported in patients with hepatic presentations. Associations with imaging abnormalities have not been systematically tested.

Objective

The aim was to determine the neuroanatomical basis for cognitive deficits in WD.

Methods

We performed a 16-item neuropsychological test battery and magnetic resonance brain imaging in 40 patients with WD. The scores for each test were compared between patients with neurological and hepatic presentations and with normative data. Associations with Unified Wilson's Disease Rating Scale neurological examination subscores were examined. Quantitative, whole-brain, multimodal im

SUBMITTER: Shribman S 

PROVIDER: S-EPMC9542291 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature