Cellular expression of epigenetic markers and oxidative stress in periodontitis lesions of smokers and non-smokers.

ABSTRACT:

Objective

To evaluate differences in the cellular expression of epigenetic markers and oxidative stress in periodontitis lesions between current smokers and non-smokers.

Background

Tobacco smoking is recognized as one of the major risk factors for periodontitis. However, the mechanisms by which smoking affects the progression of the disease remain to be determined.

Methods

Twenty-five current smokers and 21 non-smokers with generalized severe periodontitis were included. From each patient, one soft tissue biopsy from a periodontitis site was harvested and prepared for histological analysis. The infiltrated connective tissue (ICT) was selected as the region of interest to assess the cellular expression of epigenetic markers and reactive oxygen/nitrogen species (RONS) b

SUBMITTER: Dionigi C 

PROVIDER: S-EPMC9542336 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature