Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle.

ABSTRACT: The transition of stem cells from quiescence to proliferation enables tissues to self-repair. The signaling mechanisms driving these stem-cell-status decisions are still unclear. Ca²⁺ and the extracellular signal-regulated kinase (Erk1/2) are two signaling pathways that have the potential to coordinate multiple signals to promote a specific cellular response. They both play important roles during nervous system development but their roles during spinal cord and muscle regeneration are not fully deciphered. Here we show in Xenopus laevis larvae that both Ca²⁺ and Erk1/2 signaling pathways are activated after tail amputation. In response to injury, we find that Erk1/2 signaling is activated in neural and muscle stem cells and is necessary for spinal cord and skeletal mu

SUBMITTER: Levin JB 

PROVIDER: S-EPMC9542431 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature