Role of SLC4 and SLC26 solute carriers during oxidative stress.

ABSTRACT: Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by various exchangers to transport other ions and organic substrates across cell membranes and plays a critical role in cell and systemic pH homoeostasis. Chloride/bicarbonate (Cl^- /HCO₃^- ) exchangers are abundantly expressed in erythrocytes and epithelial cells and, as a consequence, are particularly exposed to oxidants in the systemic circulation and at the interface with the external environment. Here, we review the physiological functions and pathophysiological alterations of Cl^- /HCO₃^- exchangers belonging to the solute carriers SLC4 and SLC26 superfamilies in relation to oxidative stress. Particularly well studied is the impact of oxida

SUBMITTER: Remigante A 

PROVIDER: S-EPMC9542443 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature