The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.

ABSTRACT: Synapses are a primary pathological target in neurodegenerative diseases. Identifying therapeutic targets at the synapse could delay progression of numerous conditions. The mitochondrial protein SFXN3 is a neuronally enriched protein expressed in synaptic terminals and regulated by key synaptic proteins, including α-synuclein. We first show that SFXN3 uses the carrier import pathway to insert into the inner mitochondrial membrane. Using high-resolution proteomics on Sfxn3-KO mice synapses, we then demonstrate that SFXN3 influences proteins and pathways associated with neurodegeneration and cell death (including CSPα and Caspase-3), as well as neurological conditions (including Parkinson's disease and Alzheimer's disease). Overexpression of SFXN3 orthologues in Drosophila models of Parkinso

SUBMITTER: Ledahawsky LM 

PROVIDER: S-EPMC9542548 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature