Effect of sacubitril/valsartan on investigator-reported ventricular arrhythmias in PARADIGM-HF.

ABSTRACT:

Aims

Sudden death is a leading cause of mortality in heart failure with reduced ejection fraction (HFrEF). In PARADIGM-HF, sacubitril/valsartan reduced the incidence of sudden death. The purpose of this post hoc study was to analyse the effect of sacubitril/valsartan, compared to enalapril, on the incidence of ventricular arrhythmias.

Methods and results

Adverse event reports related to ventricular arrhythmias were examined in PARADIGM-HF. The effect of randomized treatment on two arrhythmia outcomes was analysed: ventricular arrhythmias and the composite of a ventricular arrhythmia, implantable cardioverter defibrillator (ICD) shock or resuscitated cardiac arrest. The risk of death related to a ventricular arrhythmia was examined in time-updated models. The interaction betw

SUBMITTER: Curtain JP 

PROVIDER: S-EPMC9542658 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature