Dipeptidyl peptidase-4 cell surface expression marks an abundant adipose stem/progenitor cell population with high stemness in human white adipose tissue.

ABSTRACT: The capacity of adipose stem/progenitor cells (ASCs) to undergo self-renewal and differentiation is crucial for adipose tissue homoeostasis, regeneration and expansion. However, the heterogeneous ASC populations of the adipose lineage constituting adipose tissue are not precisely known. In the present study, we demonstrate that cell surface expression of dipeptidyl peptidase-4 (DPP4)/cluster of differentiation 26 (CD26) subdivides the DLK1^-/CD34⁺/CD45^-/CD31^- ASC pool of human white adipose tissues (WATs) into two large populations. Ex vivo, DPP4⁺ ASCs possess higher self-renewal and proliferation capacity and lesser adipocyte differentiation potential than DDP4^- ASCs. The knock-down of DPP4 in ASC leads to significant

SUBMITTER: Hatzmann FM 

PROVIDER: S-EPMC9542856 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature