SATB1 ensures appropriate transcriptional programs within naive CD8⁺ T cells.

ABSTRACT: Special AT-binding protein 1 (SATB1) is a chromatin-binding protein that has been shown to be a key regulator of T-cell development and CD4⁺ T-cell fate decisions and function. The underlying function for SATB1 in peripheral CD8⁺ T-cell differentiation processes is largely unknown. To address this, we examined SATB1-binding patterns in naïve and effector CD8⁺ T cells demonstrating that SATB1 binds to noncoding regulatory elements linked to T-cell lineage-specific gene programs, particularly in naïve CD8⁺ T cells. We then assessed SATB1 function using N-ethyl-N-nitrosourea-mutant mice that exhibit a point mutation in the SATB1 DNA-binding domain (termed Satb1^m1Anu/m1Anu ). Satb1^m1Anu/m1Anu mice exhibit diminished SATB1-bindin

SUBMITTER: Nussing S 

PROVIDER: S-EPMC9542893 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature