Genetic and epigenetic analysis of the serotonin 2A receptor in the context of cocaine abuse.

ABSTRACT: Despite more than 2 million American cocaine users monthly, there is no approved drug for treating cocaine use disorder. Cocaine use disorder has a multifactorial aetiology, including both genetic and environmental factors. Both cocaine use and genetic variations demonstrably alter DNA methylation and gene expression in the brain in a complex manner. How these factors interact in the context of cocaine abuse in humans is unknown. We propose that we can identify potential drug targets for treating cocaine use disorders by examining genetic, epigenetic, and expression changes in the brains of individuals that abused cocaine. In this study, we identified the interaction between the epigenetics changes (DNA CpG methylation) and genetic variants (SNPs) in the HTR2A gene in the context of

SUBMITTER: Alrfooh A 

PROVIDER: S-EPMC9543049 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature