Therapeutic Targeting of MYC in Head and Neck Squamous Cell Carcinoma.

ABSTRACT: MYC plays critical roles in tumorigenesis and is considered an attractive cancer therapeutic target. Small molecules that directly target MYC and are well tolerated in vivo represent invaluable anti-cancer therapeutic agents. Here, we aimed to investigate the therapeutic effect of MYC inhibitors in head and neck squamous cell carcinoma (HNSCC). The results showed that pharmacological and genetic inhibition of MYC inhibited HNSCC proliferation and migration. MYC inhibitor 975 (MYCi975), inhibited HNSCC growth in both cell line-derived xenograft and syngeneic murine models. MYC inhibition also induced tumor cell-intrinsic immune responses, and promoted CD8⁺ T cell infiltration. Mechanistically, MYC inhibition increased CD8⁺ T cell-recruiting chemokines by inducin

SUBMITTER: Liu S 

PROVIDER: S-EPMC9543056 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature