A strategy of vascular-targeted therapy for liver fibrosis.

ABSTRACT:

Background and aims

No effective treatments are available for liver fibrosis. Angiogenesis is deeply involved in liver fibrogenesis. However, current controversial results suggest it is difficult to treat liver fibrosis through vascular targeting. There are three different microvessels in liver: portal vessels, liver sinusoids, and central vessels. The changes and roles for each of the three different vessels during liver fibrogenesis are unclear. We propose that they play different roles during liver fibrogenesis, and a single vascular endothelial cell (EC) regulator is not enough to fully regulate these three vessels to treat liver fibrosis. Therefore, a combined regulation of multiple different EC regulatory signaling pathway may provide new strategies for the liver fibrosis the

SUBMITTER: Lin Y 

PROVIDER: S-EPMC9543235 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature