Bone mineral density in very low birthweight adults-A sibling study.

ABSTRACT:

Background

Children and adults born very low birthweight (VLBW, <1500 g) at preterm gestations have lower bone mineral density (BMD) and/or bone mineral content (BMC) than those born at term, but causality remains unknown.

Objectives

Our aim was to assess BMD and BMC in adults born at VLBW in a sibling comparison setting to account for shared genetic and environmental confounders.

Methods

We conducted a cohort study of 77 adults born VLBW and 70 same-sex term-born siblings at mean age of 29 years. The primary outcome variables were BMD Z-scores, and BMC, of the femoral neck, lumbar spine, and whole body, measured using dual-energy X-ray absorptiometry. We analysed data by linear mixed models.

Results

The VLBW adults had a 0.25 (95% CI 0.02, 0.47) Z-score unit l

SUBMITTER: Sandboge S 

PROVIDER: S-EPMC9543339 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature