Peripheral Polyfunctional PD1⁺ CD8⁺ T cells demonstrated strong immune protection in non-small cell lung cancer.

ABSTRACT: Higher frequencies of polyfunctional PD1⁺ CD8⁺ T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1⁺ CD8⁺ T cells demonstrated strong immune protection. This study also provided a potential combined treatment strategy with anti-PD1 and CAR-T therapy.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9543371 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature