Intrahepatic cholestasis of pregnancy - Time to redefine the reference range of total serum bile acids: A cross-sectional study.

ABSTRACT:

Objective

To establish pregnancy-specific reference ranges for fasting and postprandial total serum bile acid (TSBA) concentrations.

Design

Cross-sectional study.

Setting

Tertiary-care university hospital.

Population

Healthy pregnant women at term admitted to the Obstetrics Department over a period of 1 year. Exclusion criteria were an established diagnosis of intrahepatic cholestasis of pregnancy (ICP) or any coexisting condition of increased risk for ICP.

Methods

Both fasting (after 8-14 h of fasting) and postprandial (2 h after meal) TSBA concentrations were measured in 612 women (with 528 fasting samples and 377 postprandial samples) by automated enzymatic spectrophotometric assay.

Main outcome measures

Fasting and postprandial TSBA concentrat

SUBMITTER: Huri M 

PROVIDER: S-EPMC9543426 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature