Topographic organization of the human caudate functional connectivity and age-related changes with resting-state fMRI.

ABSTRACT: The striatum is postulated to play a central role in gating cortical processing during goal-oriented behavior. While many human neuroimaging studies have treated the striatum as an undivided whole or several homogeneous compartments, some recent studies showed that its circuitry is topographically organized and has more complex relations with the cortical networks than previously assumed. Here, we took a gradient functional connectivity mapping approach that utilizes the entire anatomical space of the caudate nucleus to examine the organization of its functional relationship with the rest of the brain and how its topographic mapping changes with age. We defined the topography of the caudate functional connectivity using three publicly available resting-state fMRI datasets. We replicated an

SUBMITTER: O'Rawe JF 

PROVIDER: S-EPMC9543452 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature