Effect of an ear cleaner instillation containing lipacids in a model of re-acidification of the external auditory canal in dogs.

ABSTRACT:

Background

In humans, the acidic pH of the ear canal plays a protective role against infection and a change towards alkalinity of the external auditory canal (EAC) is a local factor in the progression of acute to chronic otitis externa (OE). The use of acidic preparations alone for treatment of OE without concurrent antibiotic use is well-documented in humans. In dogs, only one study has investigated the EAC pH in healthy dogs and in dogs with OE, and investigations to understand the role of EAC pH in the pathogenesis of canine OE are lacking.

Hypothesis/objectives

To obtain physiological EAC pH values in beagle dogs. To develop a model of re-acidification of the EAC in dogs and to investigate how an acidic solution may accelerate the return to a physiological pH.

Animals

SUBMITTER: Panzuti P 

PROVIDER: S-EPMC9543456 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature