Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3.

ABSTRACT:

Background and purpose

Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures.

Methods

To evaluate total tau (t-tau), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and neurofilament light-chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers (n = 143) and controls (n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD-1 platform. Eleven ATXN3 mutation carrier cerebrospinal fluid samples were analysed for t-tau and phosphorylated tau (p-tau¹⁸¹ ). A transgenic SCA3 mouse model (MJDTg) was used to measure cerebellar t-tau levels.

Results

Plasma t-tau levels were higher in mutation carriers below

SUBMITTER: Garcia-Moreno H 

PROVIDER: S-EPMC9543545 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature