Predictive performance of pharmacokinetic models for target concentration-controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery.

ABSTRACT: We aimed to evaluate the predictive performance of previously constructed free (C_free ) and total (C_total ) cefoxitin pharmacokinetic models and the possibility of administering cefoxitin via the target-controlled infusion (TCI) method in clinical practice. Two external validation studies (N = 31 for C_free model, N = 30 for C_total model) were conducted sequentially. Cefoxitin (2 g) was dissolved in 50 mL of normal saline to give a concentration of 40 mg mL^-1 . Before skin incision, cefoxitin was infused with a TCI syringe pump. Target concentrations of free concentration and total concentration were set to 25 and 80 μg mL^-1 , respectively, which were administered throughout the surgery. Three arterial blood samples were coll

SUBMITTER: Kang HU 

PROVIDER: S-EPMC9543581 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature