Re-parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.

ABSTRACT: African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about infection dynamics and outbreak potential in these naive populations. In order to better inform a previously published ordinary differential equation model, we performed a systematic literature search to identify studies documenting experimental infection of naive (control) equids in vaccination trials. Data on the time until the onset of viraemia, clinical signs and death after experimental infection of a naive equid and duration of viraemia were extracted. The time to viraemia was 4.6 days and the time to clinical signs was 4.9 days, longer

SUBMITTER: Fairbanks EL 

PROVIDER: S-EPMC9543668 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature