Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest.

ABSTRACT:

Background

Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest.

Methods

This systematic review and meta-analysis will be conducted based on a systematic search of relevant major medical databases from their inception onwards, including MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as clinical trial registries. We will identify randomised controlled trials published in the English language that compare targeting a MAP higher than 65-70 mmHg in CA patients using vasopressors, in

SUBMITTER: Skrifvars MB 

PROVIDER: S-EPMC9543739 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature