Obesity-associated metabolites in relation to type 2 diabetes risk: A prospective nested case-control study of the CARRS cohort.

ABSTRACT:

Aims

To determine whether obesity-associated metabolites are associated with type 2 diabetes (T2DM) risk among South Asians.

Materials and methods

Serum-based nuclear magnetic resonance imaging metabolomics data were generated from two South Asian population-based prospective cohorts from Karachi, Pakistan: CARRS1 (N = 4017) and CARRS2 (N = 4802). Participants in both cohorts were followed up for 5 years and incident T2DM was ascertained. A nested case-control study approach was developed to select participants from CARRS1 (N_cases  = 197 and N_controls  = 195) and CARRS2 (N_cases  = 194 and N_controls  = 200), respectively. First, we investigated the association of 224 metabolites with general obesity based on body mass index and with

SUBMITTER: Ali MK 

PROVIDER: S-EPMC9543742 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature