Risk factors for RhD immunisation in a high coverage prevention programme of antenatal and postnatal RhIg: a nationwide cohort study.

ABSTRACT:

Objective

To evaluate which risk factors for RhD immunisation remain, despite adequate routine antenatal and postnatal RhIg prophylaxis (1000 IU RhIg) and additional administration of RhIg. The second objective was assessment of the current prevalence of RhD immunisations.

Design

Prospective cohort study.

Setting

The Netherlands.

Population

Two-year nationwide cohort of alloimmunised RhD-negative women.

Methods

RhD-negative women in their first RhD immunised pregnancy were included for risk factor analysis. We compared risk factors for RhD immunisation, occurring either in the previous non-immunised pregnancy or in the index pregnancy, with national population data derived from the Dutch perinatal registration (Perined).

Results

In the 2-year coho

SUBMITTER: Slootweg YM 

PROVIDER: S-EPMC9543810 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature