Proton-Gradient-Driven Sensitivity Enhancement of Liposome-Encapsulated Supramolecular Chemosensors.
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ABSTRACT:
SUBMITTER: Nilam M
PROVIDER: S-EPMC9543936 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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Proton-Gradient-Driven Sensitivity Enhancement of Liposome-Encapsulated Supramolecular Chemosensors.
Nilam Mohamed M Karmacharya Shreya S Nau Werner M WM Hennig Andreas A
Angewandte Chemie (International ed. in English) 20220713 35
An overarching challenge in the development of supramolecular sensor systems is to enhance their sensitivity, which commonly involves the synthesis of refined receptors with increased affinity to the analyte. We show that a dramatic sensitivity increase by 1-2 orders of magnitude can be achieved by encapsulating supramolecular chemosensors inside liposomes and exposing them to a pH gradient across the lipid bilayer membrane. This causes an imbalance of the influx and efflux rates of basic and ac ...[more]
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