Limited evidence of patient-to-patient transmission of Staphylococcus aureus strains between children with cystic fibrosis, Queensland, Australia.

ABSTRACT:

Objectives

Here we used whole genome sequencing (WGS) to understand strain diversity and potential for patient-to-patient transmission of Staphylococcus aureus among children with cystic fibrosis (CF) in Queensland, Australia.

Methods

S. aureus isolates (n = 401) collected between January 2018 and April 2019 from 184 patients with CF (n = 318 isolates) and 76 patients without CF (n = 83 isolates) were subjected to WGS and subsequent multilocus sequence typing (MLST), and a phylogeny was constructed from core genome single nucleotide polymorphism (SNP) analysis. The subsequent data was compared with available patient information.

Results

WGS revealed that patients with CF were essentially colonised by the same genotypes as those seen in patients without CF. Sequence ty

SUBMITTER: Biggs SL 

PROVIDER: S-EPMC9543978 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature