Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [¹⁸ F]FMPEP-d₂.

ABSTRACT:

Background

The endocannabinoid system is a widespread neuromodulatory system affecting several biological functions and processes. High densities of type 1 cannabinoid (CB1) receptors and endocannabinoids are found in basal ganglia, which makes them an interesting target group for drug development in basal ganglia disorders such as Parkinson's disease (PD).

Objective

The aim of this study was to investigate CB1 receptors in PD with [¹⁸ F]FMPEP-d₂ positron emission tomography (PET) and the effect of dopaminergic medication on the [¹⁸ F]FMPEP-d₂ binding.

Methods

The data consisted of 16 subjects with PD and 10 healthy control subjects (HCs). All participants underwent a [¹⁸ F]FMPEP-d₂ high-resolution rese

SUBMITTER: Ajalin RM 

PROVIDER: S-EPMC9544132 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature