A minority of somatically mutated genes in pre-existing fatty liver disease have prognostic importance in the development of NAFLD.

ABSTRACT:

Background

Understanding the genetics of liver disease has the potential to facilitate clinical risk stratification. We recently identified acquired somatic mutations in six genes and one lncRNA in pre-existing fatty liver disease. We hypothesised that germline variation in these genes might be associated with the risk of developing steatosis and contribute to the prediction of disease severity.

Methods

Genome-wide association study (GWAS) summary statistics were extracted from seven studies (>1.7 million participants) for variants near ACVR2A, ALB, CIDEB, FOXO1, GPAM, NEAT1 and TNRC6B for: aminotransferases, liver fat, HbA1c, diagnosis of NAFLD, ARLD and cirrhosis. Findings were replicated using GWAS data from multiple independent cohorts. A phenome-wide association study w

SUBMITTER: Mann JP 

PROVIDER: S-EPMC9544140 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature