The growth-survival trade-off is hard-wired in the Lactococcus lactis gene regulation network.

ABSTRACT: Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non-spore-forming Lactococcus lactis KF147 progressively activates the expression of stress-associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 10⁴ -fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress-tolerance adaptations underlying the growth-survival trade-off in L. lactis, and exemplify the hard-wiring of this trade-off in the lactococcal gene regulation network.

SUBMITTER: Ercan O 

PROVIDER: S-EPMC9544163 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature