Risk-reducing mastectomy decisions among women with mutations in high- and moderate- penetrance breast cancer susceptibility genes.

ABSTRACT:

Background

Women harboring mutations in breast cancer susceptibility genes are at increased lifetime risk of developing breast cancer and are faced with decisions about risk management, including whether to undergo high-risk screening or risk-reducing mastectomy (RRM). National guidelines recommend BRCA1 or BRCA2 mutation carriers consider RRM, but that carriers of moderate penetrance mutations (e.g., ATM or CHEK2) should be managed based on family history. We aimed to investigate determinants of decision for RRM, and hypothesized that mutation status, age, family history, partner status, and breast cancer would impact RRM decision making.

Methods

We performed a retrospective study assessing RRM decisions for 279 women.

Results

Women with BRCA and moderate penetrance

SUBMITTER: Comeaux JG 

PROVIDER: S-EPMC9544212 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature