Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study.

ABSTRACT:

Background

Methods for accurate quantification of lung fluid in heart failure (HF) are needed. Dynamic contrast-enhanced (DCE)-MRI may be an appropriate modality.

Purpose

DCE-MRI evaluation of fraction of fluid volume in the interstitial lung space (v_e ) and vascular permeability (K^trans ).

Study type

Prospective, single-center method validation.

Population

Seventeen evaluable healthy volunteers (HVs), 12 participants with HF, and 3 with acute decompensated HF (ADHF).

Field strength/sequence

T₁ mapping (spoiled gradient echo variable flip angle acquisition) followed by dynamic series (three-dimensional spoiled gradient-recalled echo acquisitions [constant echo time, repetition time, and flip angle at 1.5 T]).

Assessmen

SUBMITTER: Cheriyan J 

PROVIDER: S-EPMC9544235 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature